My ninth IVF cycle was full of twists and turns. At one point, it felt like it was going to be the worst cycle, but in the end, it became the one where I had my first real “victory”.
Given my age and repeated IVF failures, I was exploring all options, including Human Growth Hormone (HGH). I learned that it isn’t just used to promote growth in children; it’s also used by adults, like gym enthusiasts, for building muscles (illegal??), and is even considered as an off-label treatment in IVF to potentially improve egg and embryo quality. This encouraged me to ask my doctor for a prescription. I needed to know the dosage, frequency, timing, and duration of injections. He didn’t give me a straight answer, repeating that there wasn’t a protocol and insufficient research for IVF use. He never actually said no, but the first time he told me I was on my own, I knew what he meant. I understood his position—he couldn’t risk his career prescribing something unofficial, though I was willing to take responsibility. Although some sources suggested HGH wasn’t beneficial for IVF, given my circumstances and the lack of identified major risks, I decided to take the chance and manage the HGH injections myself.
In IVF, the most commonly used HGH is Omnitrope, but I couldn’t find it in VN. In fact, finding HGH there wasn’t easy at all. The only type available to me was Saizen, which I had read about being used in IVF treatments in Australia.
I’d bought one box of 6 mg Saizen as a sample to show it to my doctor, hoping to convince him to prescribe HGH for me. However, 1.5 months later, when I tried to buy more, it was no longer available, and no one could tell me when it might be back on the market. This scarcity was completely unexpected. Though I called many big pharmacies, I still had no luck.
The only place I hadn’t contacted was the National Children’s Hospital, so I decided to give it a try as a last resort. I had avoided hospital pharmacies before because they usually required doctors’ prescriptions, which I didn’t have. On my way to the hospital’s main gate, I noticed many pharmacies lining the street, so I thought, why not stop by one of them first?
The pharmacy didn’t have the hormone I needed in stock, but after several calls, the owner said he could get a different one for me. The new one was Genotropin, but it shared the same main active ingredient. And I would have to wait until the next day as the drug was being brought in by air. This informal import method, known as “Hàng xách tay” (hand-carried goods), is quite common in Vietnam.
HGH protocols vary widely in terms of dosage, total injection days, and timing. Some doctors recommend starting injections on the first day of stimulation and continuing until the egg retrieval day. Others suggest priming with HGH weeks before stimulation and continuing through the process until the booster shot. Some patients only use it for a few days during stimulation.
Based on what I had read, I decided to take 1mg per day, starting from the first stimulation day until the booster shot. This seemed to be the most common protocol I came across. I aligned the timing with my stimulation injections, which made things easier. Using Saizen was simple and straightforward, the Genotropin pen was a nightmare to set up. The instructions were confusing, and the pen’s design was far more complicated compared to Saizen.
I nervously tried to set the dose, worried I’d break the pen. If that happened, I’d be totally screwed. I just couldn’t figure it out, and as the time I was supposed to inject came and went, I got even more anxious. Finally, I gave up and ran to the nearest hospital to ask for help.





At first, some of the staff I asked thought it would be simple, but they quickly realized the drug was quite special and unfamiliar to them. Since I didn’t have a prescription, most of them refused to assist me. Only one doctor stayed, saying she could tell by my expression that I was desperately seeking help. Together, we watched YouTube videos and followed the manual, trying to figure out how to set up the pen. She twisted and turned the pen’s knob vigorously while I was afraid she might break the pen. Finally it worked. I was super relieved at first but then felt so bummed when I realized I’d lost half the drug during setting it up.
Deep down, I was still grateful that, thanks to her help, I was finally able to take the injection. Since the pen came with a larger dose—12 mg, the only option available—instead of the smaller dose I had originally intended to buy, I was fortunate to still have enough medication left, even after losing half of it.
The ninth cycle could have been a huge disappointment for me, but in the end, it brought so many unexpected surprises.
At the baseline ultrasound, everything looked good with two follicles on the left and two on the right. I started daily injections of Puregon 300 IU from 06/08/24, added IVF 75 IU from 06/12/24 and Orgalutran from 06/14/24. However, during the stimulation process, my follicles developed very slowly. Midway through, one follicle grew much larger than the others, which was not ideal, as I hoped for more evenly growing follicles. I continued with the stimulation, hoping the smaller follicles would catch up with the larger one, but unfortunately, that didn’t happen. The largest follicle measured 19 mm while the second one was 10 mm. My doctor then recommended a dual stimulation cycle, where I would undergo egg retrieval to collect the large follicle and immediately continue stimulation to encourage the growth of the remaining follicles.
At first, I was hesitant, worried that I might end up with nothing. Many people fail to get any embryos, even after retrieving a lot of eggs, so I wasn’t sure how things would go with just one follicle. It’s also common to retrieve fewer eggs than the baseline number. I was leaning toward the idea of ignoring the large follicle and letting the smaller ones continue to grow. However, both the doctor and a patient I spoke with suggested that the large follicle might actually be the best, as it could have the most nutrients. That reasoning made sense to me.
I underwent egg retrieval after seven days of stimulation, preparing for none to be retrieved, but luckily I secured two eggs, and both fertilized successfully. Amazingly, according to the embryologist, the embryos’ quality had improved significantly. Both showed good cell division, normal morphology, and minimal fragmentation on day three, and one even had the potential to reach the blastocyst stage by day five. Also, this time around, I didn’t have the bad pain like I did after egg retrievals in the past. I think the anesthesiologist adjusted my meds after I told them how bad it was then, and it made a huge difference.
This result might be devastated to many IVF patients, but for me, it was a milestone, marking a big improvement after so many attempts to just get one good egg and then a good embryo. Though the embryos weren’t graded as “good”, the embryologist said they were much better, which meant the whole world to me.
I took a break of four or five days after the egg retrieval but continued injecting HGH before starting the second phase of stimulation. Unfortunately, the follow-up ultrasound showed that all the follicles were gone or as the doctor put it, “ruptured.” So, I never got the chance to experience the dual stimulation process.
As for my two embryos, I didn’t want to risk waiting until day five because they were all I had, and I didn’t want to lose them. Usually, the number of embryos that develop on day five is much lower than than the number of embryos on day three. For patients with fewer embryos, doctors typically recommend freezing or transferring on day three. So, I decided to freeze my two embryos on day three.
At first, I thought about a fresh transfer because my progesterone was fine. I once had a day-3 embryo in the US, but at that time, my body wasn’t ready for a fresh transfer because my progesterone was high. Unfortunately, that one didn’t make it past dat four.
After thinking it over, I decided not to go for a fresh transfer. I wanted one more cycle to hopefully collect more embryos. Maybe the next cycle would be the one that maximized the benefits of the PRP and HGH injections. After a month of HGH priming and PRP injections, I was hoping for a better outcome. Given my age, my low ovarian reserve, and poor egg quality, I didn’t want to miss this “golden” opportunity to gather more embryos. If I did a fresh transfer, it could delay another egg retrieval, and with so many uncertainties along the way, it could end up wasting precious time. So, I made the decision to hold off on the fresh transfer.
After nine cycles, I finally saw some improvements in the quality of my embryos. I finally got three day-3 embryos to freeze (I wasn’t too hopeful about the one from the 8th cycle due to its very poor quality), and freezing it on day three wasn’t really my choice—it was just what I had to do to avoid losing it). The ninth cycle was a milestone, showing some progress, which renewed my hope. Instead of freezing two embryos in one tube, I decided to freeze them separately. While this meant higher storage costs and would double the transfer costs, I didn’t want to risk losing everything at once in case both embryos didn’t work. By transferring one at a time, I could hold onto hope if the first one didn’t succeed. That was how I dealt with my emotional stress.
In short, the ninth cycle was like a roller coaster. I started off “high” on PRP and HGH, hoping they would improve my results, then felt down as the follicles grew unevenly, and I faced the possibility of no eggs after retrieval. But then I was back up with two decent day-3 embryos and the hope of collecting more during the second stimulation phase. The ride leveled out when dual stimulation didn’t happen, but in the end, I was still happy with the results.















































































