IVF Cycle 8

When my seventh IVF cycle failed after all the efforts I’d put into improving my fertility health, I went through the darkest days of my life—days I will never forget. I was losing so much of myself, something I never expected. The toll this journey took on me was beyond anything I could have imagined. I felt pressed and crushed. You would never know the depth of it until you’re already caught in that spiral, and by then, it’s too late to back off without pain or exhaustion.

I don’t think words can be enough to express how I felt, or maybe I’m just not capable of expressing it through words. All I can say is that I was living through the hardest days of my life. It was a lonely journey, one I accepted because it was my choice, whether voluntary or not. I had love and support—more than I ever expected—so there was no reason to moan about it. My focus was on doing my best to deserve the good things I had received along this challenging path.

My eighth cycle began with a host of fertility issues: endometriosis, low egg ovarian reserve, poor egg quality, and poor sperm quality. It felt like every obstacle was in my way.

I had been focusing on eating healthy, staying active, going to bed early, and minimizing stress, but the results still hadn’t improved. To prepare for this cycle, I added acupressure and reflexology twice a week, and my acupuncturist had me doing acupuncture every day except Sundays. I also researched a method called PRP (Platelet-Rich Plasma), which has been used recently in the US and other developed countries. It’s said to help rejuvenate ovaries, potentially improving the quality of eggs by up to 50%. There was a lot of debate about this method, with some people dismissing it as just a marketing gimmick, while others considered it a game-changer. On Reddit, many IVF patients who tried it shared positive results. However, it was completely new in Vietnam. The only information I could find here was a short YouTube clip from a scientific conference—it wasn’t educational, just an introductory video.

When I brought up this method to my doctor, he was surprised I’d heard of this since at that time, PRP injections were still being researched and hadn’t yet received national medical approval there.

I shared the documents and videos I had collected in English for his reference. He said he could go ahead with it, but I would have to take full responsibility for any consequences. That wasn’t a problem for me because I trusted him, and I knew this method was relatively safe since it uses the patient’s own blood.

I was scheduled for PRP injections really quickly, on day 6 of my cycle. One of the things I really appreciate about treatments in Vietnam is how flexible the timing is. You don’t have to wait long to book an appointment, and this flexibility extends to almost every step of the medical process, saving a lot of time on administration, preparation, and procedures.

On the day of the procedure, the doctor drew two tubes of my blood and injected around 4 ml of plasma into my ovaries while I was under anesthesia. Afterward, I felt fine, just experiencing some light cramps and more discharge than usual, which lasted a few days.

For the procedure, my doctor administered two PRP injections, one in each ovary. Other doctors I’ve read about do multiple injections at different spots on the ovaries, and the amount of plasma used can vary. It really depends on the doctor and clinic, as PRP is not universally accepted or practiced the same way everywhere. A quick online search showed that PRP treatment was around $5,000 in the US, but I only paid 10 million VND (~$400) there.

Besides PRP, Human Growth Hormone (HGH) injections are also believed to help improve egg quality and have been used in the US. However, it was something completely new in VN. When I mentioned it to my doctor, he was surprised. I told him I wanted to give it a try, but he was hesitant because there wasn’t an established protocol for it yet.

During my treatment in VN, my conditions worsened, and with doctors juggling so many patients, I realized I needed to take a more proactive approach in finding ways to improve my fertility. I couldn’t expect a doctor to go beyond researching my case or take the initiative to explore new protocols or treatments that might work better for me. I used to feel upset and disappointed, wishing my doctor would do more, but over time, I understood that maybe I was expecting too much. I came to appreciate my doctor for listening to and respecting my thoughts, as well as for his support and attention. These meant a lot to me because it’s stressful for any patient to work with a doctor who assumes they know nothing.

28 days after the PRP injections on 04/18/24, I started my eighth IVF cycle on 05/16/24. I had daily injections of Pergoveris300 IU for 8 days, added Orgalutran in the mornings starting from 05/20/24, then injected a dual booster of Fertipeptil 0.1 mg and Ovitrellte 250 mg on 05/23/24. My follicles measured 17, 15 mm (L) and 17, 15 mm (R) on the booster day. I got 3 eggs retrieved and only one day-3 embryo, which was frozen the same day. The embryologist explained that the embryo would be unlikely to survive until day 5, and they don’t typically freeze embryos on day 4. The embryologist noted that the embryo’s development was abnormal during cell division, with the cells not dividing clearly, and the fragmentation percentage was over 50%, which was very high.

Having just one frozen day-3 embryo didn’t mean my results had improved, but it did help my emotions. At least I didn’t end the cycle with nothing. There was still some hope, though minimal, because if there hadn’t been, there wouldn’t have been any reason to freeze it.

Was I disappointed with the result? No. I had started to become familiar with repeated failures and unexpected occurrences. Gradually, I accepted that being a biological mother might not be for me. I was just trying to do what I could to avoid regret later on. After the eighth cycle, I started to realize the toll it had taken on my body. Since the seventh cycle, my body had ached severely after egg retrieval, even though I had few eggs retrieved. It felt like I was “paralyzed” the day after the procedure. My upper body felt stiff and tight, and whenever I moved, my muscles seemed to “retract,” making breathing incredibly painful. I had to sleep sitting up. In past cycles, I never experienced this kind of pain and never needed pain relievers after retrieval. When the pain first hit, I didn’t even remember the pain relievers I had been prescribed. This time, I took pain relievers, but they only helped a little.

The pain was a wake-up call, making me think about putting an end to this journey. I started to worry about the long-term consequences of the continuous IVF cycles. I started to accept that I had done enough. It was time to stop, take care of myself, and consider a different path.

However, since PRP injections are believed to be effective for up to three months and I still had nearly two months left, I didn’t want to miss the chance. So, I decided to continue the ninth cycle, this time trying HGH.